The dependent variable was categorized as no cognitive impairment, diagnosis with MCI, and diagnosis with dementia, with no cognitive impairment being the control omitted group in each model. As a first step in enhancing prescribing patterns for older adults with chronic diseases and reducing their risk of developing MCI or dementia, we are presenting the findings of a one year retrospective cohort study of primary care patients aged 65 and older to better understand the relationship between cognitive function, comorbidity and AC use.
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Chronic Anticholinergic Use and the Aging Brain
Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: Malaz Boustani 1 Regenstrief Institute, Inc.
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Diagnostic and Statistical Manual of Mental Disorders. M1 receptors play a central role in modulating AD-like pathology in transgenic mice.